Poison is a recurring negative status effect in Grandia. It is one of the few status effects that have appeared in every game in the main series to date.

A poisoned character will take damage each turn in battle until the affliction is removed or the character's HP reduces to zero. Poison generally lasts after battle but this is not always the case. Common ways of removing Poison are using a Poison Antidote or casting the magic Cure or Halvah.